High density lipoprotein modulates platelet function
نویسندگان
چکیده
منابع مشابه
High-Density Lipoprotein Function
Although high-density lipoproteins (HDL) possess many features that contribute to the association between elevated HDL cholesterol and protection from atherosclerosis, these lipoproteins may be modified in certain individuals and/or circumstances to become proinflammatory. The ability of HDL to inhibit or paradoxically to enhance vascular inflammation, lipid oxidation, plaque growth, and thromb...
متن کاملThe role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
متن کاملHigh density lipoprotein--quality and function.
Introduction Atherosclerosis is a focal disease of the large and medium sized arteries in areas of disturbed blood flow caused by endothelial injury, dysfunction and local inflammation [1]. Coronary heart disease (CHD) is the most common cause of death in western countries and in developing countries it accounts for over 4.5 million deaths annually [2]. Dyslipidaemia has been identified as a ma...
متن کاملReconstituted High-Density Lipoprotein Modulates Activation of Human Leukocytes
An anti-inflammatory effect of reconstituted High Density Lipoprotein (rHDL) has been demonstrated in atherosclerosis and in sepsis models. An increase of adhesion molecules as well as tissue factor expression on endothelial cells in response to inflammatory or danger signals are attenuated by the treatment with rHDL. Here we show the inhibitory effect of rHDL on the activation of human leukocy...
متن کاملThe WWOX gene modulates high-density lipoprotein and lipid metabolism.
BACKGROUND Low levels of high-density lipoprotein (HDL) cholesterol constitutes a major risk factor for atherosclerosis. Recent studies from our group reported a genetic association between the WW domain-containing oxidoreductase (WWOX) gene and HDL cholesterol levels. Here, through next-generation resequencing, in vivo functional studies and gene microarray analyses, we investigated the role o...
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ژورنال
عنوان ژورنال: Cytometry Part A
سال: 2006
ISSN: 1552-4922,1552-4930
DOI: 10.1002/cyto.a.20214